Roner Laboratory of Virology, Organotins & Microbiocides
Using a mouse model of rotavirus infection, we have demonstrated that it is possible to greatly reduce the incidence and severity of diarrhea by adding triterpenoid saponins prior to, and during, the virus exposure period.
Two widely employed pancreatic cell lines were used in the studies-AsPC-1 which is an adenocarcinoma pancreatic cell line and PANC-1 which is an epithelioid carcinoma pancreatic cell line. The AsPC-1 represents the most common form of pancreatic cancer.
We developed the first Reverse Genetics System for a dsRNA Virus with 10 or more genome segments
We mapped the minimial 5' and 3' encapsidation signals present in the reovirus ssRNAs
We identified a new antiviral activity in Quillaja saponins that interfers with viral attachment
The saponin extract was active in vivo preventing gastroenteritis in a rotavirus mouse model
We demonstrated that water-soluble organotin polymers destroy pancreatic tumor cells in vivo.
We discovered a novel antitumor activity of organotin polymers/monomers
1. Roner, M.R.; Carraher, C.E.; Miller, L.; Frank, J.; Mosca, F.; Slawek, P.; Haky, J.E.; Campbell, A. 2020. Metallocene Polymers as Antiviral Zika Virus Agents from the Lewis Bases Lamivudine and Camphoric Acid. World Journal of Pharmaceutical Research. Volume 9: (10);1-18. Accepted 8/16/2020. Impact factor 8.084.
Roner, M.R.; Carraher, C.E.; Miller, L.; Mosca, F.; Slawek, P.; Haky, J.E.; Frank, J. 2020. Organotin Polymers as Antiviral Agents Including Inhibition of Zika and Vaccinia Viruses. Journal of Inoganic Oganometallic Polymers. 30, 684–694 (2020).